Chemistry and Pharmacology - Organic Chemistry and drugs.pdf

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TABLE OF CONTENTS
Preface................................................................................. 1
Safety..................................................................................4
Equipment, Technique and Reagents..............................................7
Crystallization....................................................................... 10
Chromatography....................................................................
15
Distillation........................................................................... 18
Reductions...........................................................................30
Amphetamines......................................................................40
Hallucinogens . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 53
THCs................................................................................70
Analgesics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 85
Hypnotics, Sedatives And Tranquilizers.........................................98
Buying P r e c u r s o r s . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 107
Making Precursors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 1 5
The Work A r e a . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 131
AdditionalInformationS o u r c e s . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .137
A b b r e v i a t i o n s . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 138
Chemical Sources Nationwide...................................................140
G l o s s a r y . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .142
Understanding The Periodic Table.............................................. 145
Miscellaneous T a b l e s . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 147
Preface
1
PREFACE
Congratulations. You have just purchased the most complete and informative book on recre-
ational drug manufacture available. It is based upon a great deal of experience and a tremendous
amount of research. I have used easy to understand terms to aid in comprehension of the formulas
given and in the theory involved. I have patterned this book after what would appear to be a
college textbook or a college accredited correspondence course in illicit drug manufacturing.
Please follow carefully my instructions and advice on safety, purification, and referred to reading.
If you have any questions about even seemingly trivial details, then ask someone that knows.
Call a college professor, an analytical laboratory, or one of the chemical consulting firms that
exist in metropolitan areas. Aldrich Chemical Co. has a toll free number (1-800-558-9160) that
enables you to ask the chemist on duty questions concerning what you may need to order from
them and what cheaper analogs you may be able to substitute in the formula that you are
interested in. Something that may appear to be insignificant may turn out to be the difference
between completing or failing a formula and this chemist on duty gets paid to answer any
questions you may have. Do not be afraid to ask them (many other chemical suppliers have this
type of service also), but do not be a total idiot in doing this. Use common sense, read up on
your subject thoroughly and then you will sound like a legitimate operation, not a clandestine
drug lab. You will also be able to understand this person instead of having his educated talk go
in one ear and out the other. Try not to let them realize what you're making, if possible, find
another use for the chemicals or reaction that is not illegal and tell them that is what you're doing.
Never give a real name or address, if possible.
Always put safety and caution before time, ease, and expense. If these formulas can be carried
out by taking short cuts or by using cheaper reagents, then the scientists who invent them will
explain how to do them this way. I have a total hatred towards underground chemists who rush
out impure, improperly made drugs with unclean, half-assed equipment. These people are not
chemists at all and deserve to go to prison. If I heard of someone running this type of operation
I would turn them into the police personally. They take the fun out of recreational drugs and
replace it with danger. I do not intend this book to be used for making drugs, but maybe the
chemists who are producing drugs will use this material to make better, healthier drugs.
Most drugs are made from or with highly toxic or poisonous chemicals, if used improperly
they can cause disease, cancer, or immediate death. Even the most simple of chemical reactions
are not to be taken lightly or unprofessionally. Go to a college or some other type of professional
laboratory and ask if they will show you around; seven times out of ten they will give you a
tour. Look over their equipment; notice the cleanliness of even the floor. Look at the chemists
themselves; see how serious and professional they act. This is how your laboratory should look.
2
RECREATIONAL DRUGS
As I said above, I do not want to have this book used for the illicit manufacture of drugs, but
if you are going to, or have been making drugs, then I have accomplished everything if I have
taught you how to make them right. Many analogs of some drugs can be legal to produce, but
this does not mean that you can skimp on purification or other important operations described
in the formulas. I do not approve of "kitchen crank" or other high speed, slipshod operations.
This is how drugs get much of their bad reputation. If drugs were not illegal, we could buy them
from major pharmaceutical manufacturers and eliminate much of the bad dope that is being
abused today. Unfortunately, we have given up many of our rights over the years, due to ignorant,
hypocritical assholes in positions of power, and we are forced to make these drugs ourselves. So
we must act as though we are the major pharmaceutical manufacturers and we need to force our-
selves to abide by the same rigid rules that the Food and Drug Administration imposes upon them.
Besides, the recreational drug abusers are paying good money, they deserve good drugs, after all
they're only trying to have a good time.
Laboratories, like any other investment, require a certain amount of capital to start and operate.
Spend the necessary cash to buy the proper equipment to do the procedures required. Faulty
equipment (not to mention insufficient knowledge) can cause fires, explosions, asphyxiation, and
many other hazards. You can have one hell of a nice laboratory for the price of a funeral these
days. Also hospitals are in excess of $150 a day if you are not in intensive care or requiring special
services. $150 a day can operate even the most elaborate of laboratories. Therefore, if you have
to beg, borrow, or steal to obtain a functional laboratory, then do so. Is three to five thousand
dollars too much to spend on a lab that can easily produce a quarter of a million dollars worth
of THC every week? It takes money to make money, but very few, if any, investments can pay
off as well as an underground laboratory run by competent chemists.
Although this book is written in easy to understand language and the formulas have been
greatly simplified, they should not be attempted by the chemically incompetent. The chemically
incompetent are those who never took, passed or remember freshman college level chemistry. I
suppose that if you were an A student in high school chemistry, you may be smart enough to
understand what you're doing with these formulas. If you do not fall into these categories, then
stop reading this book right now. You have no business in an organic laboratory.
Most of the organic compounds listed in this book are highly flammable and have irritating,
toxic, and/or poisonous vapors. Many of the reactions in the following formulas are potentially
violent and if performed improperly will become violent. If people understand why atoms and
molecules behave the way they do under all conditions, they will know how much reagents to
use, how fast to add the reagents, what kinds of poisonous byproducts may be formed and what
dangers are involved. It is not enough for me to tell you that heating this and that, then reducing
it makes a drug. This is unprofessional and dangerous. I want you to understand
why
you do
what is required of you to complete a given formula, and a basic knowledge of chemistry is a
definite prerequisite. If you forgot, or never knew the meaning of enthalopy, chemical bonding
(ionic, polar, non-polar, bond energies), elemental and molecular properties, proton donating,
dynamic equilibrium, entropy, reaction mechanism, orbital, phase, redox, pH, photon, rate of
reaction, atomic mass, reduction, etc., etc., then you must put down this book and read one or
more of the following references until you completely understand what is going on while you
are performing these or any other formulas or reactions:
NEW ORGANIC CHEMISTR Y,
by H.L. Keys
PRACTICAL ORGANIC CHEMISTRY,
by Vogel
Preface
3
ORGANIC CHEMISTRY,
by Butler & Berlin
PRINCIPLES OF ORGANIC CHEMISTRY,
by Geissman
C.R.C. HANDBOOK OF LABORATORY SAFETY
BASIC PRINCIPLES OF ORGANIC CHEMISTR Y,
by Roberts & Caserio
PRINCIPLES OF MEDICINAL CHEMISTRY,
by Foye
This is a short list. Hundreds of good chemistry books are available at any library or book
store. It should only take a week or two to read and the importance of this cannot be overstressed.
Try to find one that has questions at the end of each chapter, so you can see if you can answer
the questions. If you can, great, go on to the next chapter; if not, read it again, Reading is nothing
without understanding.
These books will teach you how to solve and balance chemical equations, find molecular
weights, how to double or triple the scale of your formula (multiplying the given formula by two
or three rarely works as rates of reaction and dynamic equilibrium change much more differently
as the mass of reagents and precursors are increased) and other necessary information. I would
like to have included this information but it would take several decades to do so and the finished
book would be longer than four holy bibles combined. With so many good chemistry books
available, it would be impractical for me to- do this.
Most of you will not heed my advice to read some chemistry literature until after you waste
$800 worth of chemicals on one small mistake or maybe it will take a laboratory explosion to
explain how important some simple chemistry book can be.
4
RECREA T1ONAL DRUGS
SAFETY
Before commencing any procedures in organic chemistry, you must become familiar with the
safety, hazards, apparatus and methods described here in this book and in the referred reading.
Those of you who think "I don't need to learn all this preliminary bullshit, because the formula
is in easy to understand language" are wrong — dead wrong.
It is true I have reworded the formulas so that the average high school student can understand
and complete the operation easily. However, I do not have time to warn the unknowing and
incompetent every time a potential hazard is encountered, as most every chemical has dangerous
properties. Ethyl ether, as an example, has more BTU's than dynamite and is much more easily
ignited. I will not waste time or paper to describe the properties or dangers of every chemical
encountered in every formula. It is the duty of any chemist, amateur or professional, to learn these
properties. Know what you're dealing with at all times, under all conditions. I have taken much
time compiling a superb glossary of most every chemical, operation and apparatus encountered
in this book. If you find something I have not listed in the glossary, or if you use a formula not
listed in this book, do
not
assume it to be unimportant. Look it up in the
Merck Index
and
remember its properties.
Anyone who has been asphyxiated or even seen some large third degree bums caused by
chemicals or heat, will be able to relate to the rigid safety measures I will impose on you in this
chapter.
FORES
A small fire extinguisher is cheap and very effective. It should be purchased and located in
an accessible position before any chemistry is undertaken. I have known underground chemists
that thought it more important to spend $40 on a glass flask than to spend that same $40 on
a simple little fire extinguisher. One such chemist experienced a small fire that escalated into a
massive inferno, destroying hundreds of dollars worth of glassware, chemicals, books and
thousands of dollars of property. A small fire extinguisher would have stopped the small fire before
it became out of control, even for the local fire department. Also, all fire calls must be investigated
by the fire marshall, who would undoubtedly call the authorities when discovering that the cause
of the fire was a drug laboratory. The result, an easy bust.
Other fire prevention items include:
1.
A fire blanket.
This is useful for tossing onto table tops and floor fires. Even more important,
it can be used to wrap around yourself or a helper who has caught fire. These blankets can
be made easily and cheaply by going to fabric or upholstery stores and purchasing a generous

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