EBOOK Antidepressants and Receptor Function CIBA Foundation Symposium.pdf

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EBOOK Antidepressants and Receptor Function

CIBA Foundation Symposium

Wiley

Ciba Foundation Symposium 123 Antidepressants and Receptor Function Chairman: Dennis Murphy 1986

Depression is a common and often debilitating affective disorder. Attempts to develop effective

antidepressants have a long history, but many questions remain about the mechanisms of action of such

treatments and about the aetiology and pathophysiology of depression itself. Early observations centred

attention on central monoamine systems, and animal studies suggested that changes in

beta-adrenoceptor responsiveness were a common effect of antidepressant therapies. More recent

research has encompassed many different central and peripheral receptors, time-dependent adaptational

events at synapses, and the functional significance of changes in neurotransmitter systems in both

humans and experimental animals. Such pharmacological studies aimed ultimately at elucidating the

neurochemical basis of depression and of promoting new therapeutic approaches, provide the focus of this

symposium volume. Many different methods of investigating the links between monoamine systems,

depression and antidepressant treatments are described. Recent studies of receptors and of monoamine

uptake sites in the brain and the periphery (e.g. in platelets and fibroblasts) are reviewed, with emphasis

on alpha and beta adrenoceptors, [3H]imipramine-binding sites and serotonin receptors. The results of

monitoring amine metabolites in cerebrospinal fluid and of measuring neuroendocrine, physiological and

behavioural responses to pharmacological challenge are presented, providing information on

monoaminergic function in depressed patients and experimental animals before, during and after

treatment with antidepressant drugs or electroconvulsive shock. Genetic influences on receptor density

are also discussed, as is the relevance to human depressive illness of animal models, including

stress-induced behavioural depression in rats and responses to social stressors in rhesus monkeys. This

book should be of interest to neuropharmacologists, psychopharmacologists, clinical pharmacologists,

behavioural scientists, psychiatrists and neuroscientists. Related Ciba Foundation Symposia: No 117

Photoperiodism, melatonin and the pineal Chairman: R. V. Short 1985 ISBN 0 471 91086 4 No 126 Selective

Neuronal Death Chairman: H. M. Wisniewski 1987 ISBN 0 471 91092 9

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