Pravin Bhatt (Eds.)-Viral and Mycoplasmal of Laboratory Rodents. Effects on Biomedical Research-Elsevier Science (1986).pdf

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Academic Press Rapid Manuscript Reproduction
Based on a conference on Viral and Mycoplasmal Infections of Laboratory
Rodents: Effects on Biomédical Research, held on October 24-26, 1984, at the
National Institutes of Health.
Viral and Mycoplasmal
Infections
of Laboratory Rodents
Effects on Biomédical Research
Edited by
Pravin N. Bhatt
Robert O. Jacoby
Section of Comparative Medicine
Yale University School of Medicine
New Haven, Connecticut
Herbert C. Morse III
Laboratory of Immunopathology
National Institute of Allergy and Infectious Diseases
National Institutes of Health
Bethesda, Maryland
Albert E. New
Office of Laboratory Animal Science
National Cancer Institute
Bethesda, Maryland
ACADEMIC PRESS, INC.
Harcourt Brace Jovanovich, Publishers
Orlando San Diego New York
Boston London Sydney Tokyo
Austin
Toronto
COPYRIGHT © 1986 BY ACADEMIC PRESS. INC
ALL RIGHTS RESERVED.
NO PART OF THIS PUBLICATION MAY BE REPRODUCED OR
TRANSMITTED IN ANY FORM OR BY ANY MEANS. ELECTRONIC
OR MECHANICAL, INCLUDING PHOTOCOPY. RECORDING. OR
ANY INFORMATION STORAGE AND RETRIEVAL SYSTEM. WITHOUT
PERMISSION IN WRITING FROM THE PUBLISHER.
ACADEMIC PRESS, INC.
Orlando. Florida 32887
United Kingdom Edition published bx
ACADEMIC PRESS INC. (LONDON) LTD.
24-28 Oval Road, London NW1 7DX
Library of Congress Cataloging in Publication Data
Viral and mycoplasmal infections of laboratory rodents.
Proceedings of a conference held at the National
Institutes of Health on Oct. 24-26, Ί984.
Includes index.
1. Laboratory animals-Diseases-Congresses.
2. Rodents—Diseases-Congresses. 3. Rodents as labora-
tory animals-Congresses. 4. Veterinary virology-
Congresses. 5. Mycoplasma diseases in animals-
Congresses. 6. Laboratory infections—Congresses.
1. Bhatt, Pravin N. [DNLM: 1. Animals, Laboratory-
congresses. 2. Mycoplasma Infections—veterinary—
congresses. 3. Rodent Diseases—congresses. 4. Virus
Diseases-veterinary-congresses. SF 997.5.R5 V813 1984]
SF996.5.V57 1986
616.9'2
86-47798
ISBN 0 - 1 2 - 0 9 5 7 8 5 - X (alk. paper)
PRINTED IN THE UNITED STATES OE AMERICA
86 87 88 89
9 8 7 6 5 4 3 21
Preface
In 1966 a landmark conference, the first to address collectively viral infec-
tions of laboratory rodents, was held at the Center for Disease Control in
Atlanta, Georgia. During the ensuing two decades, understanding of the
biology, pathogenesis, and epizootiology of these infections has expanded
significantly and recognition of potential interference by these infections in the
conduct of animal-related research has increased. Therefore it seemed timely
to collate new information about rodent viruses and to reconsider their impact
on research using laboratory rodents.
An enthusiastic and knowledgeable group of scientists formed a planning
committee. They drew up plans for a national conference to facilitate dialogue
among groups with an abiding interest in rodent viral infections.
The planning committee also recognized that mycoplasmosis is a major
nuisance in animal-related research so they recommended that the program in-
clude recent findings pertaining to
Mycoplasma
infection.
The resulting conference on "Viral and Mycoplasmal Infections of
Laboratory Rodents: Effects on Biomédical Research" was held at the Na-
tional Institutes of Health on October 24-26, 1984. Conferees and speakers in-
cluded basic scientists, veterinarians, commercial producers, and animal
research managers.
The conference proceedings are assembled in this text. Each contributor was
asked to summarize current knowledge on her or his topic and to suggest direc-
tions for future research. Manuscripts were reviewed for thoroughness and
clarity, but considerable latitude was accepted for style and language.
We thank the authors for their contributions and cooperation. We also ex-
tend our gratitude to Mrs. Laurie Flaherty for preparing the final manuscripts,
Ms. Sujata Bhatt for proofreading the text, the staff of Academic Press for ad-
vice and patience, and Mr. Rexroad and his staff at the National Institutes of
Health for their hospitality and management of the Masur Auditorium. We
express special appreciation to Mrs. Patrick Meek and Mr. Eric Deitrich of the
Office of Laboratory Animal Science, National Cancer Institute, and Mrs.
Celeste Ouellette from the Section of Comparative Medicine, Yale School of
Medicine, for their underlying efforts in coordinating various conference-
related matters.
IX
X
Preface
We reemphasize our profound debt to Dr. Wallace P. Rowe, a giant among
biomédical scientists and a pioneer in the systematic study of rodent viruses
and viral diagnosis. He was a moving force in the planning committee until his
untimely death. We are deeply gratified that the committee chose to dedicate
the conference to him.
The National Institutes of Health participated in the support of this meeting
under Grant No. RR-01549 from the Division of Research Resources, Fogarty
International Center, National Cancer Institute, National Institute on Aging,
and the National Institute of Allergy and Infectious Diseases. Support was
also given through a grant by Hoffman-LaRoche, Inc.
Additional contributions were made by Abbott Laboratories, Merck Sharp
and Dohme Research Laboratories, E. R. Squibb and Sons, Inc., G. D. Searle
and Company, Alcide Corporation, Camm Research Lab Animals, Charles
River Laboratories, Inc., Granite Diagnostics, Inc., Harlan Spraque Dawley,
Inc., Hilltop Lab Animals, Inc., Lab Products, Inc., Metpath, Micro-
biological Associates, and Taconic Farms, Inc.
Pravin N. Bhatt
Robert O. Jacoby
Herbert C. Morse III
Albert E. New

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