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Evolutionary Algorithms
in Molecular Design
Edited
by
David
E.
Clark
BWILEY-VCH
Methods
and Principles
in Medicinal
Chemistry
Edited by
R.
Mannhold
H.
Kubinyi
H.
Timmerman
Editorial Board
G.
Folkers,
H.-D.
Holtje,
J.
Vacca,
H.
van de Waterbeemd, T. Wieland
Evolutionary Algorithms
in Molecular Design
Edited
by
David
E.
Clark
@WILEY-VCH
Weinheim
.
New
York
.
Chichester
.
Brisbane
.
Singapore
.
Toronto
Series Editors:
Prof. Dr. Raimund Mannhold
Biomedical Research Center
Molecular Drug Research Group
Heinrich-Heine-Universitat
UniversitatsstraBe
1
40225 Diisseldorf
Germany
Volume Editor:
Dr. David
E.
Clark
Computer-Aided Drug Design
Aventis Pharma Ltd.
Dagenham Research Centre
Rainham Road South
Dagenham
Essex RMlO 7XS
United Kingdom
Prof. Dr. Hugo Kubinyi
ZHFIG,
A
30
BASF AG
67056 Ludwigshafen
Germany
Prof.
Dr.
Hendrik Timmerman
Faculty of Chemistry
Dept.
of
Pharmacochemistry
Free University of Amsterdam
De Boelelaan 1083
1081
HV Amsterdam
The
Netherlands
This book was carefully produced. Nevertheless, authors, editors and publisher do not warrant the
information contained therein to be free of errors. Readers are advised to keep in mind that statements,
data, illustrations, procedural details or'other items may inadvertently be inaccurate.
Library
of
Congress Card No. applied
for.
British Library Cataloguing-in-Publication Data:
A
catalogue record for this book is available from the British
Library.
Die Deutsche Bibliothek
-
CIP Cataloguing-in-Publication-Data
A catalogue record for this publication is available from Die Deutsche Bibliothek
ISBN 3-527-30155-0
0
WILEY-VCH Verlag GmbH, D-69469 Weinheim (Federal Republic of Germany),
2000
Printed on acid-free and chlorine-free paper.
All rights reserved (including those of translation into other languages). No part of the book may be reproduced
in any form
-
by photoprinting, microfilm,
or
any other means
-
nor transmitted or translated into a machine
language without written permission from the publishers. Registered names, trademarks, etc. used in this book,
even when not specifically marked as such, are not to be considered unprotected by law.
Composition: Datascan GmbH. D-67346 Speyer
Printing: Strauss Offsetdruck. D-69509 Morlenbach
Bookbinding: I. Schaffer GmbH
&
Co. KG., D-67269 Griinstadt
Printed in the Federal Republik
of
Germany.
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