The Scientist 2018 03.pdf

(11824 KB) Pobierz
MARCH 2018 | WWW.THE-SCIENTIST.COM
The Transgender
Brain
RESEARCHERS SEEK CLUES TO THE ORIGINS
OF GENDER DYSPHORIA
ANCIENT
PROTEINS
UNEARTHED
AUTOPHAGY
IN SICKNESS
AND HEALTH
GETTING CRISPR
ON TARGET
HOW TO FORGE
ACADEMIC/INDUSTRY
PARTNERSHIPS
PLUS
Your ULT freezers should be as revolutionary as
your research . . .
With a Stirling Ultracold freezer . . .
Your samples will never be safer.
Because there are no compressors, the field-proven
Stirling Engine continuously modulates and adapts to
maintain remarkable temperature stability. With no oil
or valves to maintain and only two moving parts, there
is simply far less that can go wrong with our cooling
system.
Stirling Engine
The free-piston Stirling
engine's advanced
integral linear motor
system has only two
moving parts and
uses a gravity-driven
thermosiphon to cool
the cabinet interior.
Thermosiphon
Your energy costs will never be lower.
Not only does our SU780XLE use 70-75% less energy
than standard compressor-based ULT freezers, but was
validated as the industry’s most energy-efficient model,
by a wide margin, as it earned the EPA's first ENERGY
STAR® certification for ultra-low temperature freezers.
Visit
NoCompressors.com
to learn
how this is all made possible with our
revolutionary Stirling Engine.
No Compressors. Safer Samples.
Call
855-274-7900
or visit
stirlingultracold.com
for more information
be
INSPIRED
drive
DISCOVERY
stay
GENUINE
Did you get
the message?
In recent years, the discovery of new classes and
modifications of RNA has ushered in a renaissance
of RNA-focused research. Did you know that
NEB
®
offers a broad portfolio of reagents for the
purification, quantitation, detection, synthesis
and manipulation of RNA? Experience improved
performance and increased yields, enabled
by our expertise in enzymology.
FEATURED PRODUCTS
for
RNA RESEARCH:
NEW
Monarch
®
Total
RNA Miniprep Kit
rapidly purify up to 100 μg
of high quality total RNA
from multiple sample types
Luna
®
One-Step
RT-qPCR kits
improve RT-qPCR
performance with our
novel, Luna WarmStart
®
Reverse Transcriptase
NEW
NEBNext
®
Ultra
II RNA
Library Prep kits
generate high quality
RNA-seq libraries, even with
limited amounts of RNA
HiScribe
in vitro
transcription kits
rapidly synthesize
high yields of
high quality RNA
Let NEB help streamline your
RNA-related workflows.
Get started at
NEBrna.com
One or more of these products are covered by patents, trademarks and/or copyrights owned or controlled by New England Biolabs, Inc. For more information, please email us at gbd@neb.com.
The use of these products may require you to obtain additional third party intellectual property rights for certain applications. © Copyright 2018, New England Biolabs, Inc.; all rights reserved.
MARCH 2018
Contents
THE SCIENTIST
THE-SCIENTIST.COM
VOLUME 32 NUMBER 3
© ANA YAEL; CHRISTINA WARINNER; © N.R. FULLER, SAYO-ART LLC
Features
ON THE COVER: ILLUSTRATION BY ANA YAEL
26
The Transgender Brain
Researchers are probing the neural roots
of gender dysphoria.
BY SHAWNA WILLIAMS
34
The Ghosts of Proteins Past
The field of paleoproteomics is gathering
steam in its quest to use ancient peptides
to explore the history of life on Earth.
BY CATHERINE OFFORD
42
Eating Yourself to Live
As researchers uncover new molecular
details of the process of autophagy,
potential therapeutic targets emerge.
BY VIKRAMJIT LAHIRI AND
DANIEL J. KLIONSKY
03.2018 | THE SCIENTIST
3
Zgłoś jeśli naruszono regulamin