The Diversity of Gastric Carcinoma - M. Kaminiski, et al., (Springer, 2005) WW.pdf - książki - Bio Med 25 - bibiariel

M. Kaminishi, K. Takubo, K. Mafune (Eds.)

The Diversity of Gastric Carcinoma

Pathogenesis, Diagnosis, and Therapy

M. Kaminishi, K. Takubo, K. Mafune (Eds.)

The Diversity of

Gastric Carcinoma

Pathogenesis, Diagnosis,

and Therapy

With 172 Figures, Including 97

in Color

Michio Kaminishi, M.D., Ph.D.

Departments of Gastrointestinal Surgery, Surgical Metabolic Care and Endocrine

Surgery, The University of Tokyo Graduate School of Medicine

7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655,Japan

Kaiyo Takubo, M.D., Ph.D.

Human Tissue Research Group, Tokyo Metropolitan Institute of Gerontology

35-2 Sakaecho, Itabashi-ku, Tokyo 173-0015,Japan

Ken-ichi Mafune, M.D., Ph.D., F.A.C.S.

Department of Gastrointestinal Surgery

The University of Tokyo Graduate School of Medicine

7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655,Japan

This book was ﬁnancially supported by the Japan Society for the Promotion of Science

(Grant-in-Aid for Publication of Scientiﬁc Research Results: Grant No. 175300).

Library of Congress Control Number: 2005921446

ISBN 4-431-21139-X Springer-Verlag Tokyo Berlin Heidelberg New York

This work is subject to copyright. All rights are reserved, whether the whole or part of the material is

concerned, speciﬁcally the rights of translation, reprinting, reuse of illustrations, recitation, broad-

casting, reproduction on microﬁlms or in other ways, and storage in data banks.

The use of registered names, trademarks, etc. in this publication does not imply, even in the absence

of a speciﬁc statement, that such names are exempt from the relevant protective laws and regulations

and therefore free for general use.

Product liability: The publisher can give no guarantee for information about drug dosage and appli-

cation thereof contained in this book. In every individual case the respective user must check its accu-

racy by consulting other pharmaceutical literature.

Springer is a part of Springer Science + Business Media

springeronline.com

Printed in Japan

Typesetting: SNP Best-set Typesetter Ltd., Hong Kong

Printing and binding: Shinano, Inc., Japan

Printed on acid-free paper

Foreword

It is an honor to be asked to comment on the occasion of the publication of The Diver-

sity of Gastric Carcinoma: Pathogenesis, Diagnosis, and Therapy , edited by Prof.

Michio Kaminishi, Dr. Takubo, and Dr. Mafune. This book provides a very valuable,

wide coverage of molecular carcinogenesis and prevention, through to diagnosis and

treatment of stomach neoplasia. A particularly important aspect for gastric cancer

control is the biological diversity of the tumors themselves. The stomach is a compli-

cated organ, and the cardiac and pyloric portions have different cellular compositions

and functions. The many types of cells are in a constant ﬂux of differentiation from

stem cells. Precancerous conditions such as intestinal metaplasia and atrophic gastri-

tis are well known, and there are various factors that have already been established as

promoting cancer development. They include sodium chloride intake, infection of

Helicobacter pylori , and the host genetic background. It is therefore not surprising that

stomach cancers demonstrate great diversity in their biological and clinical behavior.

The practical consequence is that the clinical handling that is most suitable for each

individual patient is also diverse. Each chapter of this volume is well presented by

authors who are specialized in fundamental and clinical sciences and who are cur-

rently active at the forefront of their own ﬁelds. The entire book is compiled taking

into account the most up-to-date knowledge, with a balanced viewpoint. This book

should be widely recommended to researchers and clinicians dealing with one of most

ugly and common diseases of mankind, gastric cancer.

Takashi Sugimura

President Emeritus, National Cancer Center

Chairman of Section II, The Japan Academy

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